Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy.


Bioconjugates composed of chlorotoxin and near-infrared fluorescent (NIRF) moieties are being advanced toward human clinical trials as intraoperative imaging agents that will enable surgeons to visualize small foci of cancer. In previous studies, the NIRF molecules were conjugated to chlorotoxin, which results in a mixture of mono-, di-, and trilabeled… (More)
DOI: 10.1021/jm101018r