Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism.

@article{Craney2012ChemicalPO,
  title={Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism.},
  author={Arryn Craney and Cory J Ozimok and Sheila Marie Pimentel-Elardo and Alfredo Capretta and Justin R Nodwell},
  journal={Chemistry & biology},
  year={2012},
  volume={19 8},
  pages={1020-7}
}
Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and for many other medicinal applications. The mechanisms that limit the production of these molecules in the laboratory are not well understood, and this has impeded the discovery of many important compounds. We have identified small molecules that remodel the yields of secondary metabolites in many actinomycetes and show that one set of these molecules does so by inhibiting fatty acid biosynthesis. This… CONTINUE READING

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