Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish.

@article{Bayliss2006ChemicalMO,
  title={Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish.},
  author={Peter Bayliss and Kimberly L Bellavance and Geoffrey G Whitehead and Joshua M Abrams and Sandrine Aegerter and Heather S Robbins and Douglas B. Cowan and Mark T. Keating and Terence M O'Reilly and Jeanette Marjorie Wood and Thomas M Roberts and Joanne P Chan},
  journal={Nature chemical biology},
  year={2006},
  volume={2 5},
  pages={265-73}
}
We examined the role of angiogenesis and the need for receptor signaling using chemical inhibition of the vascular endothelial growth factor receptor in the adult zebrafish tail fin. Using a small-molecule inhibitor, we were able to exert precise control over blood vessel regeneration. An angiogenic limit to tissue regeneration was determined, as avascular… CONTINUE READING