Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.

@article{Rao2008ChemicalMO,
  title={Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.},
  author={G. S. Subba Rao and P. Kondaiah and S. Singh and P. Ravanan and M. Sporn},
  journal={Tetrahedron},
  year={2008},
  volume={64 51},
  pages={
          11541-11548
        }
}
Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid and boswellic acids, by modification of A-ring with a cyano- and enone- functionalities, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bio-assays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyanoenones of boswellic acid and glycyrrhetinic acid. 
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