Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties.

@article{Lapierre1996ChemicalMO,
  title={Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties.},
  author={F Lapierre and Kevin R Holme and L S Lam and Robert J. Tressler and Neal Storm and J. T. K. Wee and R J Stack and John J Castellot and Dr. D. A. J. Tyrrell},
  journal={Glycobiology},
  year={1996},
  volume={6 3},
  pages={355-66}
}
Structural features of heparin potentially important for heparanase-inhibitory activity were examined by measuring the ability of heparin derivatives to affect the degradation of [3H]acetylated heparan sulphate by tumor cell heparanases. IC50 values were determined using an assay which distinguished degraded from undegraded substrate by precipitation of the latter with cetylpyridinium chloride (CPC). Removal of heparin's 2-O-sulphate and 3-O-sulphate groups enhanced heparanase-inhibitory… CONTINUE READING

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