Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.

@article{Swenson2009ChemicalMO,
  title={Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.},
  author={Dana L. Swenson and Kelly Lyn Warfield and Travis K Warren and Candace E. Lovejoy and Jed N. Hassinger and Gordon Ruthel and Robert E. Blouch and Hong M. Moulton and Dwight D. Weller and Patrick L. Iversen and Sina Bavari},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 5},
  pages={2089-99}
}
Phosphorodiamidate morpholino oligomers (PMOs) are uncharged nucleic acid-like molecules designed to inactivate the expression of specific genes via the antisense-based steric hindrance of mRNA translation. PMOs have been successful at knocking out viral gene expression and replication in the case of acute viral infections in animal models and have been well tolerated in human clinical trials. We propose that antisense PMOs represent a promising class of therapeutic agents that may be useful… CONTINUE READING

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