Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization.

@article{Gentilucci2010ChemicalMD,
  title={Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization.},
  author={Luca Gentilucci and Rossella De Marco and Lucia Cerisoli},
  journal={Current pharmaceutical design},
  year={2010},
  volume={16 28},
  pages={
          3185-203
        }
}
Functions and properties of native peptides vary from highly specific antibiotics or cytotoxic antitumor drugs, to hormones, neurotransmitters, immunomodulators, etc. Despite their potential utility as therapeutic agents, there are problems connected with the use of natural peptides, due to the low stability against proteolysis, resulting in a short duration of in vivo activity, and in a low bioavailability. One way to overcome these disadvantages is the use of modified peptides, the so called… CONTINUE READING
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