Chemical modification reduces the conductance of sodium channels in nerve

  title={Chemical modification reduces the conductance of sodium channels in nerve},
  author={Frederick J. Sigworth and Bruce C. Spalding},
Tetrodotoxin (TTX) and saxitoxin (STX) are extremely potent poisons that prevent nerve and muscle cells from producing action potentials by blocking sodium channels1,2. If the channels are modified by reagents that act on carboxyl groups, however, both the binding of these toxins3,4 and their effect on the action potential5 are reduced. One such reagent, trimethyloxonium ion (TMO) converts channels into a form that is not blocked by TTX concentrations 105 times greater than its normal Kd (ref… CONTINUE READING
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