Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor.

@article{Yates2005ChemicalMO,
  title={Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor.},
  author={Andrew S Yates and Stephen W. Doughty and David A. Kendall and Barrie Kellam},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 16},
  pages={3758-62}
}
In silico modelling was used to guide the positioning of the fluorescent dye NBD-F on the cannabinoid CB2 receptor agonist JWH-015. While the ultimate fluorescent conjugate lost extensive binding affinity to the cannabinoid CB2 receptor, affinity and efficacy studies on the naphthoyl 3-position modified precursor molecules have provided new insight into structure-activity relationships associated with this position. 

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…