Chemical modification and biological evaluation of new semisynthetic derivatives of 28,29-Didehydronystatin A1 (S44HP), a genetically engineered antifungal polyene macrolide antibiotic.

@article{Preobrazhenskaya2009ChemicalMA,
  title={Chemical modification and biological evaluation of new semisynthetic derivatives of 28,29-Didehydronystatin A1 (S44HP), a genetically engineered antifungal polyene macrolide antibiotic.},
  author={Maria N. Preobrazhenskaya and Evgenia N Olsufyeva and Svetlana E Solovieva and Anna N Tevyashova and Marina I Reznikova and Yuryi N Luzikov and Larisa P. Terekhova and Aleksei S Trenin and Olga A Galatenko and Ivan D Treshalin and Elena P. Mirchink and Vladimir M Bukhman and H{\aa}vard Sletta and Sergey B Zotchev},
  journal={Journal of medicinal chemistry},
  year={2009},
  volume={52 1},
  pages={189-96}
}
Twenty-three new derivatives of the heptaene nystatin analogue 28,29-didehydronystatin A(1) (1) (S44HP) were obtained by chemical modification of C16 carboxyl and amino groups of mycosamine. These derivatives comprised 15 carboxamides, 4 N-alkyl derivatives, 3 N-derivatives containing additional N-linked monosaccharide or disaccharide moiety (products of Amadori rearrangement), and 1 N-aminoacyl derivative. The derivatives have been tested in vitro against yeasts Candida albicans, Cryptococcus… CONTINUE READING