Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control.

@article{Scott2002ChemicalMO,
  title={Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control.},
  author={Adam Charles Scott and Roland Wensel and Constantinos H. Davos and Michael Kemp and Agnieszka Kaczmarek and James Hooper and Andrew J. Stewart Coats and Massimo Francesco Piepoli},
  journal={Circulation},
  year={2002},
  volume={106 2},
  pages={214-20}
}
BACKGROUND The overactivity of ergoreceptors (intramuscular afferents sensitive to products of skeletal muscle work) may be responsible for the abnormal responses to exercise and symptoms of exercise intolerance in chronic heart failure (CHF); however, little is known of the chemical nature of the stimuli involved. We investigated biochemical factors (H+, VCO2, VO2, HCO3, K+, phosphate, lactate, PGE2, PGF(1alpha), and bradykinin) potentially involved in ergoreceptor activation. METHODS AND… CONTINUE READING