Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents.

@article{Bardos1979ChemicalMO,
  title={Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents.},
  author={T. Bardos and J. A. Dunn and M. Perlman},
  journal={International journal of radiation oncology, biology, physics},
  year={1979},
  volume={5 9},
  pages={
          1653-6
        }
}
Abstract Three 2,2-dimethyl phosphoraziridines, bis(2,2-dimethylaziridinyl)phosphinyl urethane (AB-132, NSC 51325), ethyl bis(2,2-dimethylaziridinyi)phosphinate (AB-163 NSC 108878) and bis(2,2-dimethylaziridinyl)-N-hydroxyurethane (AB-182, NSC 200724) which have shown synergistic antitumor effects in conjunction with X-irradiation, are characterized by their rapid hydrolysis via S N 1-mechanism and via the formation of transient 5-membered cyclic intermediates exhibiting phosphorylating… Expand
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