Chemical mechanism of insulin action via proteolytic formation of mediator peptides

In 1972 (1) we proposed a novel chemical mediator of insulin action. We next announced the discovery of an insulin-generated substance which inhibited the cyclic AMP-dependent protein kinase in 1976 (2). In 1979 (3) we demonstrated the existence of a chemical mediator of insulin action which had intracellular effects: it Specifically inhibited cyclic AMP… CONTINUE READING