Chemical lesioning and glutamate administration reveal a major role for the nucleus tractus solitarius in the cardiac-somatic reflex in rats.

@article{Liu2012ChemicalLA,
  title={Chemical lesioning and glutamate administration reveal a major role for the nucleus tractus solitarius in the cardiac-somatic reflex in rats.},
  author={Xiaoheng Liu and Nan Sun and J-Q Du and J S Tang and Man Hyup Han and J-X Zhu and F-Q Huo},
  journal={Neuroscience},
  year={2012},
  volume={207},
  pages={326-32}
}
Many patients suffer from secondary muscle hyperalgesia after experiencing angina pectoris. In this study, we examined the role of the nucleus tractus solitarius (NTS) and glutamate receptors in modulating cardiac-evoked muscle hyperalgesia induced by pericardial capsaicin, which was monitored by recording electromyogram (EMG) activity from the spinotrapezius muscle in the anesthetized rat. Unilateral chemical lesioning of the commissural NTS with the neurotoxin ibotenic acid significantly… CONTINUE READING