Chemical labeling and enrichment of nitrotyrosine-containing peptides.

@article{Abello2010ChemicalLA,
  title={Chemical labeling and enrichment of nitrotyrosine-containing peptides.},
  author={Nicolas Jean-Robert Abello and Bego{\~n}a Barroso and Huib A. M. Kerstjens and Dirkje S Postma and Rainer Bischoff},
  journal={Talanta},
  year={2010},
  volume={80 4},
  pages={1503-12}
}
Protein tyrosine nitration (PTN) is a post-translational modification of proteins associated with a number of inflammatory diseases. While PTN is rather selective (not all proteins are modified and within a protein, only certain tyrosines are subject to nitration), no consensus sequence has been identified. Since PTN is a low-abundance post-translational modification, it is necessary to enrich modified proteins and/or to detect them with high selectivity and sensitivity. Until now this has been… CONTINUE READING