Chemical kinetic resolution of unprotected β-substituted β-amino acids using recyclable chiral ligands.

@article{Zhou2014ChemicalKR,
  title={Chemical kinetic resolution of unprotected β-substituted β-amino acids using recyclable chiral ligands.},
  author={Shengbin Zhou and Jiang Wang and Xia Chen and Jos{\'e} Luis Ace{\~n}a and Vadim A Soloshonok and Hong Liu},
  journal={Angewandte Chemie},
  year={2014},
  volume={53 30},
  pages={7883-6}
}
The first chemical method for resolution of N,C-unprotected β-amino acids was developed through enantioselective formation and disassembly of nickel(II) complexes under operationally convenient conditions. The specially designed chiral ligands are inexpensive and can be quantitatively recycled along with isolation of the target β-substituted-β-amino acids in good yields and excellent enantioselectivity. The method features a broad synthetic generality including β-aryl, β-heteroaryl, and β-alkyl… CONTINUE READING