Chemical inhibitors when timing is critical: a pharmacological concept for the maturation of T cell contacts.

@article{Khler2005ChemicalIW,
  title={Chemical inhibitors when timing is critical: a pharmacological concept for the maturation of T cell contacts.},
  author={Karsten K{\"o}hler and Annemarie Coffman Lellouch and Susanne Vollmer and Oda Stoevesandt and Antje Hoff and Lasse Peters and Hans Rogl and Bernard Malissen and Roland Brock},
  journal={Chembiochem : a European journal of chemical biology},
  year={2005},
  volume={6 1},
  pages={152-61}
}
Cellular signal transduction proceeds through a complex network of molecular interactions and enzymatic activities. The timing of these molecular events is critical for the propagation of a signal and the generation of a specific cellular response. To define the timing of signalling events, we introduce the combination of high-resolution confocal microscopy with the application of small-molecule inhibitors at various stages of signal transduction in T cells. Inhibitors of Src-family tyrosine… CONTINUE READING