Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

  title={Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury},
  author={A. Degterev and Z. Huang and M. Boyce and Yaqiao Li and P. Jagtap and N. Mizushima and G. Cuny and T. Mitchison and M. Moskowitz and J. Yuan},
  journal={Nature Chemical Biology},
  • A. Degterev, Z. Huang, +7 authors J. Yuan
  • Published 2005
  • Biology, Medicine
  • Nature Chemical Biology
  • The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. [...] Key Result We showed that necroptosis is characterized by necrotic cell death morphology and activation of autophagy. We identified a specific and potent small-molecule inhibitor of necroptosis, necrostatin-1, which blocks a critical step in necroptosis.Expand Abstract
    1,827 Citations
    Blocking a path to cell death
    Double agents of cell death: novel emerging functions of apoptotic regulators
    • 4
    Akt and mTOR mediate programmed necrosis in neurons
    • 83
    • PDF
    Necroptosis Signaling Pathways in Stroke: From Mechanisms to Therapies
    • 8
    • Highly Influenced
    • PDF
    Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke
    • J. Yuan
    • Biology, Medicine
    • Apoptosis
    • 2008
    • 168
    Perspectives on the therapeutic modulation of an alternative cell death, programmed necrosis (review).
    • Y. Cho
    • Biology, Medicine
    • International journal of molecular medicine
    • 2014
    • 20
    • PDF
    Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury
    • 48
    • PDF
    Necroptosis in cardiovascular disease - a new therapeutic target.
    • 23
    Molecular Mechanisms of Apoptosis in Cerebral Ischemia: Multiple Neuroprotective Opportunities
    • 204


    Necrotic Death Pathway in FAS Receptor Signaling
    • 227
    • PDF
    Caspase-independent programmed cell death with necrotic morphology
    • 275
    • PDF
    Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke
    • 204
    • PDF