Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

@article{Degterev2005ChemicalIO,
  title={Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury},
  author={A. Degterev and Z. Huang and M. Boyce and Yaqiao Li and P. Jagtap and N. Mizushima and G. Cuny and T. Mitchison and M. Moskowitz and J. Yuan},
  journal={Nature Chemical Biology},
  year={2005},
  volume={1},
  pages={112-119}
}
  • A. Degterev, Z. Huang, +7 authors J. Yuan
  • Published 2005
  • Biology, Medicine
  • Nature Chemical Biology
  • The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. [...] Key Result We showed that necroptosis is characterized by necrotic cell death morphology and activation of autophagy. We identified a specific and potent small-molecule inhibitor of necroptosis, necrostatin-1, which blocks a critical step in necroptosis.Expand Abstract
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