Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.

@article{CassidyStone2008ChemicalIO,
  title={Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.},
  author={Ann Cassidy-Stone and Jerry Edward Chipuk and Elena Ingerman and Cheng Li Song and Choong Leol Yoo and Tomomi Kuwana and Mark J Kurth and Jared T Shaw and Jenny E. Hinshaw and Douglas R Green and Jodi Nunnari},
  journal={Developmental cell},
  year={2008},
  volume={14 2},
  pages={193-204}
}
Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from mitochondria, in part by controlling cristae structures. Mitochondrial division promotes apoptosis by an unknown mechanism. We addressed how division proteins regulate apoptosis using inhibitors of mitochondrial division identified in a chemical screen. The most efficacious inhibitor, mdivi-1 (for mitochondrial… CONTINUE READING
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