Chemical inhibition of autophagy: Examining its potential to increase the specific productivity of recombinant CHO cell lines.

Abstract

Chinese hamster ovary (CHO) cells activate and undergo apoptosis and autophagy for various environmental stresses. Unlike apoptosis, studies on increasing the production of therapeutic proteins in CHO cells by targeting the autophagy pathway are limited. In order to identify the effects of chemical autophagy inhibitors on the specific productivity (qp… (More)
DOI: 10.1002/bit.25962

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