Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling.

@article{Rybel2009ChemicalIO,
  title={Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling.},
  author={Bert De Rybel and Dominique Audenaert and Gregory Vert and Wilfried Rozhon and Juliane Mayerhofer and Frank Peelman and Silvie Coutuer and Tinneke Denayer and Leentje Jansen and Long Nguyen and Isabelle Vanhoutte and Gerrit T. S. Beemster and Kris Vleminckx and Claudia Jonak and Joanne Chory and Dirk Inz{\'e} and Eugenia Russinova and Tom Beeckman},
  journal={Chemistry & biology},
  year={2009},
  volume={16 6},
  pages={594-604}
}
Glycogen synthase kinase 3 (GSK3) is a key regulator in signaling pathways in both animals and plants. Three Arabidopsis thaliana GSK3s are shown to be related to brassinosteroid (BR) signaling. In a phenotype-based compound screen we identified bikinin, a small molecule that activates BR signaling downstream of the BR receptor. Bikinin directly binds the GSK3 BIN2 and acts as an ATP competitor. Furthermore, bikinin inhibits the activity of six other Arabidopsis GSK3s. Genome-wide transcript… CONTINUE READING

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