Chemical images: Technical approaches and issues

  title={Chemical images: Technical approaches and issues},
  author={Donald A. Clark and Slobodan {\vS}a{\vs}iċ},
  journal={Cytometry Part A},
Chemical mapping techniques using Raman microscopy are introduced, and using an example of a pharmaceutical tablet, the practical aspects of data collection and processing to produce a chemical image of the sample are detailed. Issues related to data processing, instrument standards, chemical image reportable errors, and the interpretation of chemical images are presented to encourage debate, develop solutions, and promote use in other challenging scientific applications. applications. © 2006… 
Pharmaceutical Applications of Chemical Mapping and Imaging
The sections in this article are Introduction The Technology and Rationale for Chemical Images Sample-Preparation Considerations for Chemical Mapping and Imaging Chemical Mapping and
Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control.
  • A. Gowen, C. O’Donnell, P. Cullen, S. Bell
  • Chemistry
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2008
Raman Microscopy : A Versatile Approach to Bio-Imaging
This chapter emphasises the unique attributes of Raman microscopy as a bioimaging technique, including its non-invasive, spectral multiplexing ability, allied with high spatial resolution and underpinned by a range of multivariate data processing methods.
Confocal Raman Microscopy in Pharmaceutical Development
This chapter will also reveal the advantages and demonstrate the synergies of Raman mapping as compared to/with similar imaging methods such as SEM/EDX, NIR and MIR imaging.
- 0501 Recent Applications of Chemical Imaging to Pharmaceutical Process Monitoring and Quality Control
Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Vibrational
Vibrational imaging of tablets by epi-detected stimulated Raman scattering microscopy.
Proper chemical imaging tools are critical to the pharmaceutical industry due to growing regulatory demand for intermediate and end-product content uniformity testing. Herein we demonstrate
Recent pharmaceutical applications of Raman and terahertz spectroscopies.
This review outlines recent applications of Raman and terahertz spectroscopies within the field of pharmaceutical research. Of the two approaches, Raman is better established and more accessible, and


Chemical image fusion. The synergy of FT-NIR and Raman mapping microscopy to enable a more complete visualization of pharmaceutical formulations.
A novel sample referencing approach has been developed that allows data to be acquired from exactly the same area of the sample using both Raman and FT-NIR microscopies and offers a more powerful method for the evaluation of pharmaceutical formulations.
Instrumentation for FT-IR Imaging
Infrared (IR) spectroscopic imaging is the complete synthesis of IR spectroscopy with sample visualization and greatly extends the capabilities of conventional IR spectroscopy. The technique can be
A comparison of Raman chemical images produced by univariate and multivariate data processing—a simulation with an example from pharmaceutical practice
A direct comparison of univariate and multivariate data analysis has been performed to show the effect of spectral noise on the quality of chemical images derived from hyper-spectral data cubes. A
Analyzing Raman Maps of Pharmaceutical Products by Sample—Sample Two-Dimensional Correlation
Sample–sample (SS) two-dimensional correlation spectroscopy is applied in this study as a spectral selection tool to produce chemical images of real-world pharmaceutical samples consisting of two, three, and four components to demonstrate that a quite simple SS 2D correlation routine can be used for producing reliable images of unknown samples.
Subsurface Raman Spectroscopy and Mapping Using a Globally Illuminated Non-Confocal Fiber-Optic Array Probe in the Presence of Raman Photon Migration
A fiber-optic probe with global illumination and an array of 50 collection fibers is used to obtain Raman spectra and 50 spatial element maps of polymers through overlayers of other polymers that are highly scattering.
Photon Migration in Raman Spectroscopy
This work represents the first detailed study of Raman photon migration under time-resolved conditions and a simple analytical model was developed that gives the correct relationship between the Raman and Tyndall decay exponents for isotropic scattering.
Orthogonal projection approach applied to peak purity assessment.
The orthogonal projection approach (OPA), a stepwise approach based on an orthogonalization algorithm, is proposed. The performance of OPA for the assessment of peak purity in HPLC-DAD is described
Factor Analysis in Chemistry
This book discusses Mathematical Formulation of Target Factor Analysis and its Applications, including Nuclear Magnetic Resonance, Chromatography, and Multimode Factor Analysis.