Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.

@article{Saito2009ChemicalGI,
  title={Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.},
  author={Sakae Saito and Aki Furuno and Junko Sakurai and Asami Sakamoto and Hae-Ryong Park and Kazuo Shin-Ya and Takashi Tsuruo and Akihiro Tomida},
  journal={Cancer research},
  year={2009},
  volume={69 10},
  pages={4225-34}
}
Glucose deprivation, a cell condition that occurs in solid tumors, activates the unfolded protein response (UPR). A key feature of the UPR is the transcription program activation, which allows the cell to survive under stress conditions. Here, we show that the UPR transcription program is disrupted by the antidiabetic biguanides metformin, buformin, and phenformin depending on cellular glucose availability. These drugs inhibit production of the UPR transcription activators XBP1 and ATF4 and… CONTINUE READING
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