Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.

@article{Burkard2007ChemicalGR,
  title={Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.},
  author={Mark E Burkard and Catherine L. Randall and St{\'e}phane Larochelle and Chao Zhang and Kevan M. Shokat and Robert P Fisher and Prasad V. Jallepalli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 11},
  pages={4383-8}
}
Polo-like kinases (Plks) play crucial roles in mitosis and cell division. Whereas lower eukaryotes typically contain a single Plk, mammalian cells express several closely related but functionally distinct Plks. We describe here a chemical genetic system in which a single Plk family member, Plk1, can be inactivated with high selectivity and temporal resolution by using an allele-specific, small-molecule inhibitor, as well as the application of this system to dissect Plk1's role in cytokinesis… CONTINUE READING
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Polo - like kinases ( Plks ) play crucial roles in mitosis and cell division .
Cell divisionProcess includes biological processMitosis
Polo - like kinases ( Plks ) play crucial roles in mitosis and cell division .
Polo - like kinases ( Plks ) play crucial roles in mitosis and cell division .
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