Chemical genetics reveals a complex functional ground state of neural stem cells.

@article{Diamandis2007ChemicalGR,
  title={Chemical genetics reveals a complex functional ground state of neural stem cells.},
  author={Phedias Diamandis and Jan Wildenhain and Ian D. Clarke and Adrian G. Sacher and Jeremy A. Graham and David S. Bellows and Erick K. M. Ling and Ryan J Ward and Leanne G Jamieson and Mike Tyers and Peter Dirks},
  journal={Nature chemical biology},
  year={2007},
  volume={3 5},
  pages={268-73}
}
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the proliferation and self-renewal of NSCs, which we refer to as the 'ground state', remains largely uncharacterized. Although the candidate gene approach has uncovered vital pathways in NSC biology, so far only a few highly… CONTINUE READING

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