Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.

@article{Xu2009ChemicalGP,
  title={Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.},
  author={Deming Xu and Susan Sillaots and John Davison and Wenqi Hu and Bo Jiang and Sarah J. Kauffman and Nick Martel and Pam Ocampo and Chanseok Oh and Steve Trosok and Karynn Veillette and Hao Wang and Minghui Yang and Li Zhang and Jeffrey Becker and Charles E. Martin and Terry W. Roemer},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 29},
  pages={19754-64}
}
The balance between saturated and unsaturated fatty acids plays a crucial role in determining the membrane fluidity. In the diploid fungal pathogen Candida albicans, the gene for fatty acid Delta9 desaturase, OLE1, is essential for viability. Using a reverse genetic approach, termed the fitness test, we identified a group of structurally related synthetic compounds that induce specific hypersensitivity of the OLE1(+/-) strain. Genetic repression of OLE1 and chemical inhibition by two selected… CONTINUE READING
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Antifungal Compounds Affecting Unsaturated Fatty Acids 19764 JOURNAL OF BIOLOGICAL CHEMISTRY

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