Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated.

@article{Zhao2007ChemicalGI,
  title={Chemical genetic interrogation of natural variation uncovers a molecule that is glycoactivated.},
  author={Yang Zhao and Tszfung F Chow and Rachel Puckrin and Simon E Alfred and Albert K. Korir and Cynthia K Larive and Sean R Cutler},
  journal={Nature chemical biology},
  year={2007},
  volume={3 11},
  pages={716-21}
}
Natural variation in human drug metabolism and target genes can cause pharmacogenetic or interindividual variation in drug sensitivity. We reasoned that natural pharmacogenetic variation in model organisms could be systematically exploited to facilitate the characterization of new small molecules. To test this, we subjected multiple Arabidopsis thaliana accessions to chemical genetic screens and discovered 12 accession-selective hit molecules. As a model for understanding this variation, we… CONTINUE READING