Chemical generation of bispecific antibodies.

  title={Chemical generation of bispecific antibodies.},
  author={Venkata Ramana Doppalapudi and Jie Huang and Dingguo Liu and Ping Jin and Bin Liu and Lingna Li and Joel Desharnais and Crystal Hagen and Nancy J Levin and Michael J. Shields and Michelle A Parish and Robert E. Murphy and Joselyn Del Rosario and Bryan D. Oates and Jing-Yu Lai and Marla J Matin and Zemeda W Ainekulu and Abhijit D Bhat and Curt W. Bradshaw and Gary Woodnutt and Richard Allen Lerner and Rodney W. Lappe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 52},
Bispecific antibodies (BsAbs) are regarded as promising therapeutic agents due to their ability to simultaneously bind two different antigens. Several bispecific modalities have been developed, but their utility is limited due to problems with stability and manufacturing complexity. Here we report a versatile technology, based on a scaffold antibody and pharmacophore peptide heterodimers, that enables rapid generation and chemical optimization of bispecific antibodies, which are termed… CONTINUE READING