Chemical form-dependent induction of hepatic zinc-thionein by arsenic administration and effect of co-administered selenium in mice.

@article{Maitani1987ChemicalFI,
  title={Chemical form-dependent induction of hepatic zinc-thionein by arsenic administration and effect of co-administered selenium in mice.},
  author={Tamio Maitani and Natsuko Saito and Mitsuyuki Abe and Susumu Uchiyama and Yukio Saito},
  journal={Toxicology letters},
  year={1987},
  volume={39 1},
  pages={63-70}
}
Four arsenic compounds (m-arsenite, arsenate, methylarsonate (MMA), and dimethylarsinate (DMA) were administered to mice, either orally or by intraperitoneal injection, and the amounts of induced hepatic zinc-thionein (Zn-Th) were determined to investigate the chemical form dependency in metallothionein induction by arsenic. Several mice died within 24 h following intraperitoneal injection. The toxicity estimated from the lethality was in the order of m-arsenite greater than arsenate much… CONTINUE READING

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