Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.

@article{Sherry2008ChemicalES,
  title={Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.},
  author={A Dean Sherry and M. Woods},
  journal={Annual review of biomedical engineering},
  year={2008},
  volume={10},
  pages={391-411}
}
Magnetic resonance imaging (MRI) contrast agents have become an important tool in clinical medicine. The most common agents are Gd(3+)-based complexes that shorten bulk water T(1) by rapid exchange of a single inner-sphere water molecule with bulk solvent water. Current gadolinium agents lack tissue specificity and typically do not respond to their chemical environment. Recently, it has been demonstrated that MR contrast may be altered by an entirely different mechanism based on chemical… CONTINUE READING
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Study of moderately rapid chemical exchange reactions by means of nuclear magnetic resonance double resonance

  • S Forsén, RA Hoffman
  • J. Chem. Phys
  • 1963
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