Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.

@article{Kingston1977ChemicalET,
  title={Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.},
  author={I. B. Kingston and B L Kingston and Frank W. Putnam},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 12},
  pages={
          5377-81
        }
}
Nine samples of human ceruloplasmin [iron(II):oxygen oxidoreductase; EC 1.16.3.1] prepared by different procedures have been examined for heterogeneity; gel electrophoresis showed that seven contained a number of components with molecular weights ranging from 20,000 to 130,000, and two contained largely a single component of molecular weight 130,000. Digestion of a single-component preparation with plasmin produced fragments with molecular weights similar to those found in the multicomponent… CONTINUE READING