Chemical engineering of mesenchymal stem cells to induce a cell rolling response.

@article{Sarkar2008ChemicalEO,
  title={Chemical engineering of mesenchymal stem cells to induce a cell rolling response.},
  author={Debanjan Sarkar and Praveen Kumar Vemula and Grace Sock Leng Teo and Dawn P. Spelke and Rohit Karnik and Le Y Wee and Jeffrey M. Karp},
  journal={Bioconjugate chemistry},
  year={2008},
  volume={19 11},
  pages={2105-9}
}
Covalently conjugated sialyl Lewis X (SLeX) on the mesenchymal stem cell (MSC) surface through a biotin-streptavidin bridge imparts leukocyte-like rolling characteristics without altering the cell phenotype and the multilineage differentiation potential. We demonstrate that the conjugation of SLeX on the MSC surface is stable, versatile, and induces a robust rolling response on P-selectin coated substrates. These results indicate the potential to increase the targeting efficiency of any cell… CONTINUE READING

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Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex

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