Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production

  title={Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production},
  author={Weifa Zheng and Kangjie Miao and Yubing Liu and Yanxia Zhao and Meimei Zhang and Shenyuan Pan and Yucheng Dai},
  journal={Applied Microbiology and Biotechnology},
Inonotus obliquus (Fr.) Pilat is a white rot fungus belonging to the family Hymenochaetaceae in the Basidiomycota. In nature, this fungus rarely forms a fruiting body but usually an irregular shape of sclerotial conk called ‘Chaga’. Characteristically, I. obliquus produces massive melanins released to the surface of Chaga. As early as in the sixteenth century, Chaga was used as an effective folk medicine in Russia and Northern Europe to treat several human malicious tumors and other diseases in… 

Phenolic compounds from the fungus Inonotus obliquus and their antioxidant properties

This study describes the isolation and structural determination of the phenolic antioxidants from the I. obliquus fruiting body as well as their antioxidant properties and searches for free radical scavengers from medicinal fungi.

Qualitative analysis of secondary metabolites of chaga mushroom (Inonotus Obliquus): phenolics, fatty acids, and terpenoids

Chaga mushroom is a black perennial fungus that usually parasites on adult birch tree trunks. It has been conventionally used as a health-promoting supplement and nutraceutical in different cultures

Comparative Analyses of Bioactive Compounds in Inonotus obliquus Conks Growing on Alnus and Betula

Inonotus obliquus grows in the Northern Hemisphere on some living broadleaved tree species as a pathogen, causing stem rot. In Estonia, the fungus is well known in the Betula species but can also be

Isolation of the Inonotus obliquus chaga mushroom strain and intensification of a culture growth during solid-phase cultivation

: The extracts from fungus Inonotus obliquus (Pers.:Fr.) Pilat (chaga), which have been widely used in medicine and cosmetics due to their high antioxidant properties, are in evergrowing demand

Stimulated production of steroids in Inonotus obliquus by host factors from birch.

Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici

The current study represents the first report on the chemical profile of I. nidus-pici, providing a comprehensive study on the isolation and structure determination of bioactive secondary metabolites of this macrofungus.

Fungi & Health: can polysaccharides from the fungus inonotus obliquus (CHAGA) inhibit tumor growth?

The present work has aimed to isolate and characterize the polysaccharides in Chaga, and several fractions showed promising results by activating murine bonemarrow derived macrophages to inhibit the growth of Lewis lung carcinoma cells in vitro.



Phenolic compounds from Inonotus obliquus and their immune stimulating effects. Mycosystema

Less production of hispidin analogs and melanins is likely to be responsible for less immune-stimulating effects in Phenolic compounds from submerged cultures, and additional factors should be imposed during submerged cultures of I. obliquus to regulate biosynthesis of phenolic compounds directed to the composition similar to Chaga.

Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga).

The antioxidant activity of hot water extract of Chaga was precisely compared with those of other medicinal fungi showing Chaga had the strongest antioxidant activity among fungi examined in terms of both superoxide and hydroxyl radicals scavenging activities.

Identification of Inonotus obliquus and Analysis of Antioxidation and Antitumor Activities of Polysaccharides

The results indicate that I. obliquus polysaccharides exhibit high antitumor and antioxidation effects, which will enable large-scale production of the poly Saccharides.

Antioxidant effect of Inonotus obliquus.

Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus.

Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.

The results demonstrated that IOE70 inhibition of LPS-induced expression of iNOS and COX-2 protein is mediated by Akt and JNK, and might have useful clinical applications in the management of inflammatory diseases and may also be useful as a medicinal food.

Sterol composition in field-grown and cultured mycelia of Inonotus obliquus.

It is suggested that the sterol composition in mycelia of the fungus can be diversified by supplementing substances inhibiting enzymatic process towards the synthesis of ergosterol.

[Physicochemical properties of melanins produced by Inonotus obliquus("chagi") in the nature and the cultivated fungus].

Physicochemical properties of pigments isolated from the naturally occurring sterile form of Inonotus obliquus (Fr.) Pil. known as Chagi and comprising the major constituent of the medicine befungin