Chemical derivatization as a strategy to enhance detectability of agents used in cancer management.

Abstract

The bioanalysis of drugs used in the management of cancer is often complicated by the lack of selectivity and sensitivity. Chemical derivatization of these drugs prior to their chromatographic analysis represents a viable strategy to improve chromatographic resolution and to enhance detectability. This review provides examples of how this approach can meet… (More)

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@article{Sternson1988ChemicalDA, title={Chemical derivatization as a strategy to enhance detectability of agents used in cancer management.}, author={Larry A. Sternson and John F. Stobaugh and T. J. Reid and Pascale De Montigny}, journal={Journal of pharmaceutical and biomedical analysis}, year={1988}, volume={6 6-8}, pages={657-68} }