Chemical cross-linking and mass spectrometry for mapping three-dimensional structures of proteins and protein complexes.

@article{Sinz2003ChemicalCA,
  title={Chemical cross-linking and mass spectrometry for mapping three-dimensional structures of proteins and protein complexes.},
  author={Andrea Sinz},
  journal={Journal of mass spectrometry : JMS},
  year={2003},
  volume={38 12},
  pages={1225-37}
}
  • Andrea Sinz
  • Published 2003 in Journal of mass spectrometry : JMS
Chemical cross-linking of proteins, an established method in protein chemistry, has gained renewed interest in combination with mass spectrometric analysis of the reaction products for elucidating low-resolution three-dimensional protein structures and interacting sequences in protein complexes. The identification of the large number of cross-linking sites from the complex mixtures generated by chemical cross-linking, however, remains a challenging task. This review describes the most popular… CONTINUE READING

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