Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst.

Abstract

Phytochemical investigation of the whole plant of Marrubium vulgare L., led to the isolation of three new secondary metabolites, 11-oxomarrubiin (1), vulgarcoside A (2) and 3-hydroxyapigenin-4'-O-(6"-O-p-coumaroyl)-beta-D-glucopyranoside (3), along with four known constituents 4-7 from the polar fractions of the methanolic extract. The structures of all compounds were deduced on the basis of NMR data and HRESI-MS measurements. The new constituents 1-3 exhibited moderate to low level of inhibition on nitric oxide (NO.) production. The compound 2 also showed a moderate inhibition on pro-inflammatory cytokine TNF-alpha. The new constituents 1-3 showed no inhibitory effect on Reactive Oxygen Species (ROS) production.

Cite this paper

@article{Shaheen2014ChemicalCO, title={Chemical constituents of Marrubium vulgare as potential inhibitors of nitric oxide and respiratory burst.}, author={Farzana Shaheen and Shagufta Rasoola and Zafar Ali Shah and Samreen Soomro and Almas Jabeen and Muhammad Ahmed Mesaik and Mohammad Iqbal Choudhary}, journal={Natural product communications}, year={2014}, volume={9 7}, pages={903-6} }