Chemical composition of Erycibe schmidtii and antiproliferative activity of scopoletin on immature dendritic cells

  title={Chemical composition of Erycibe schmidtii and antiproliferative activity of scopoletin on immature dendritic cells},
  author={Wang Ren and Yantang Wang and Q. H. He and Yue Zhou and Chunxing Li and Wenling Wang and Xiao Leng and Ting Zeng and Qiang Zou and Limei Li},
  journal={Natural Product Research},
  pages={2581 - 2588}
Abstract Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in China. Its bioactive ingredients on RA are still unclear. In this study, twenty compounds including a new caffeoylquinic acid derivative, 3-O-caffeoyl-4-O-syringoylquinic… Expand
4 Citations
Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes
The rationale for use of Porana sinensis currently on the market is discussed and the current status of the chemical compositions, pharmacological activities, quality control studies, and the development of substitutes for Erycibes plants are summarized. Expand
Current advances in naturally occurring caffeoylquinic acids: structure, bioactivity and synthesis.
  • Wenwu Liu, Jingda Li, +8 authors Qingchun Zhao
  • Medicine, Chemistry
  • Journal of agricultural and food chemistry
  • 2020
This review provides extensive coverage of naturally occurring CQAs discovered from 1990 until 2020 as well as modern isolation techniques, chemical data (including structure, biosynthesis, and total synthesis) and bioactivity are summarized. Expand
A Network Pharmacology-Based Study on the Anti-Lung Cancer Effect of Dipsaci Radix
This study indicated that DR could exhibit the anti-lung cancer effect by affecting multiple targets and multiple pathways as reflected by multicomponents and multitargets in traditional Chinese medicine. Expand
Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin.
Understanding crucial targets in these molecular signalling pathways may support the role of scopoletin as a promising naturally derived bioactive compound for the treatment of several diseases. Expand


Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species.
The findings indicate that the suppressive effects of 1 and 2 on the differentiation of preosteoclastic RAW 264.7 cells is partially due to their intracellular antioxidant capacity, as they can scavenge ROS and play an important signaling role in the differentiation process. Expand
Hepatoprotective constituents from the roots and stems of Erycibe hainanesis.
Eleven new diglycosides, erycibosides A-K (1-11), four new chlorogenic acid derivatives (14-17), and a new bis-coumarin (18), together with 21 known compounds, have been isolated from an EtOH extractExpand
Prevention of FGF-2-induced angiogenesis by scopoletin, a coumarin compound isolated from Erycibe obtusifolia Benth, and its mechanism of action.
The findings suggest that scopoletin is substantially able to attenuate FGF-2-induced angiogenesis, and it might act by directly preventing the stimulation action of F GF-2 and by indirectly decreasing the production of VEGF. Expand
Bioactive constituents of the roots of Cynanchum atratum.
A novel biphenylneolignan, 2,6,2',6'-tetramethoxy-4,4'-bis(2,3-epoxy-1-hydroxypropyl)biphenyl (1), and two new glycosides named atratoglaucosides A (2) and B (3), were isolated from the roots ofExpand
[Phenolic acid derivatives from Alchornea trewioides].
To study the chemical constituents of Alchornea trewioides, silica gel column chromatography, Sephadex LH-20, reverse phase ODS column chromatography, MCI and semi-preparative HPLC were used toExpand
Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei.
13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds ofExpand
Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways.
The findings further support that scopoletin is a candidate of angiogenesis inhibitors, and it functions by interrupting the autophosphorylation of VEGF receptor 2 (VEGFR2) and the downstream signaling pathways. Expand
Chemical constituents from the roots and stems of Erycibe obtusifolia and their in vitro antiviral activity.
  • L. Fan, Ying Wang, +6 authors W. Ye
  • Chemistry, Medicine
  • Planta medica
  • 2013
Among them, the di-O-caffeoyl quinates 8-11 displayed a potent in vitro anti-respiratory syncytial virus effect. Expand
Anatomic Localization of Immature and Mature Dendritic Cells in an Ectopic Lymphoid Organ: Correlation with Selective Chemokine Expression in Rheumatoid Synovium
The association among CCL19/21-producing cells, CCR7 expression, and mature DC accumulation is in line with the roles of these chemokines in mature C CR7+ DC homing to lymphocytic infiltrates, making chemokine/receptor complex involved in DC migration a potential therapeutic target. Expand
n-alkyl glycosides and p-hydroxybenzoyloxy glucose from fruits of Crescentia cujete
The fruits of Crescentia cujete afforded eight new compounds, along with four known compounds, acanthoside D, β-d-glucopyransoyl benzoate, (R)-1-O-β-d-glucopyranosyl-1,3-octanediol, andExpand