Chemical competition in target radical reactions: numerical simulation of the theory and comparison with measured oxygen effect on DNA damage in cells.

@article{Todd1986ChemicalCI,
  title={Chemical competition in target radical reactions: numerical simulation of the theory and comparison with measured oxygen effect on DNA damage in cells.},
  author={P. Todd and T. Nishidai and L. R{\'e}v{\'e}sz and M. Edgren},
  journal={International journal of radiation biology and related studies in physics, chemistry, and medicine},
  year={1986},
  volume={50 6},
  pages={
          1023-37
        }
}
  • P. Todd, T. Nishidai, +1 author M. Edgren
  • Published 1986
  • Chemistry, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
An intracellular radiation-chemical reaction scheme is tested in which solute and solvent radicals R. react with non-target molecules Sa (scavengers) or with target molecules (presumed to be DNA) to produce target radicals T., which may also be produced by direct ionization of DNA. The rate of target radical decomposition to become 'uncommitted damage' that the cell may repair is affected by the concentration of oxygen (O2), thiols (S) and electronaffinic sensitizers (F), which compete with one… Expand

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