Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

Abstract

The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded consistent results in patients. Here, we present a combination chemical genetic study to explore how the… (More)
DOI: 10.1038/msb.2010.32

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Owens2010ChemicalCE, title={Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication}, author={Christopher M. Owens and Christina Mawhinney and Jill M. Grenier and Ralf Marius Altmeyer and Margaret S. Lee and Alexis A. Borisy and Joseph Leh{\'a}r and Lisa Johansen}, booktitle={Molecular systems biology}, year={2010} }