Chemical characterization of a family of brain lipids that induce sleep.

@article{Cravatt1995ChemicalCO,
  title={Chemical characterization of a family of brain lipids that induce sleep.},
  author={Benjamin F. Cravatt and Oscar E Prospero-Garcia and Gary Siuzdak and Norton B. Gilula and Steven J. Henriksen and Dale L. Boger and Richard A. Lerner},
  journal={Science},
  year={1995},
  volume={268 5216},
  pages={
          1506-9
        }
}
A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results… 
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Cravatt Proceedings of the National Academy of Sciences of the United States of America
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