Chemical characterization of a family of brain lipids that induce sleep.

@article{Cravatt1995ChemicalCO,
  title={Chemical characterization of a family of brain lipids that induce sleep.},
  author={B. Cravatt and O. Prosp{\'e}ro-Garc{\'i}a and G. Siuzdak and N. B. Gilula and S. Henriksen and D. Boger and R. Lerner},
  journal={Science},
  year={1995},
  volume={268 5216},
  pages={
          1506-9
        }
}
  • B. Cravatt, O. Prospéro-García, +4 authors R. Lerner
  • Published 1995
  • Biology, Medicine
  • Science
  • A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results… CONTINUE READING
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