Chemical characterization of a family of brain lipids that induce sleep.

@article{Cravatt1995ChemicalCO,
  title={Chemical characterization of a family of brain lipids that induce sleep.},
  author={Benjamin F. Cravatt and Oscar Prosp{\'e}ro-Garc{\'i}a and Gary Siuzdak and Norton B. Gilula and Steven J. Henriksen and Dale L. Boger and Richard A Lerner},
  journal={Science},
  year={1995},
  volume={268 5216},
  pages={
          1506-9
        }
}
  • Benjamin F. Cravatt, Oscar Prospéro-García, +4 authors Richard A Lerner
  • Published in Science 1995
  • Biology, Medicine
  • A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results… CONTINUE READING

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    Cravatt Proceedings of the National Academy of Sciences of the United States of America

    • Richard A Lerner, Gary Siuzdak, Oscar Prospero-Garcia ; Steven J Henriksen, Dale L Boger, F Benjamin
    • Cravatt Proceedings of the National Academy of Sciences of the United States of America
    • 1994

    Stable URL: http://links.jstor.org/sici?sici=0027-8424%2819940927%2991%3A20%3C9505%3ACABLIF%3E2.0.CO%3B2-S 6 Cerebrodiene: A Brian Lipid Isolated from Sleep-Deprived Cats

    • Stable URL: http://links.jstor.org/sici?sici=0027-8424%2819940927%2991%3A20%3C9505%3ACABLIF%3E2.0.CO%3B2-S 6 Cerebrodiene: A Brian Lipid Isolated from Sleep-Deprived Cats

    and Notes 4 Cerebrodiene: A Brian Lipid Isolated from Sleep-Deprived Cats

    • and Notes 4 Cerebrodiene: A Brian Lipid Isolated from Sleep-Deprived Cats