Chemical biology of peroxynitrite: kinetics, diffusion, and radicals.

  title={Chemical biology of peroxynitrite: kinetics, diffusion, and radicals.},
  author={Gerardo Ferrer-Sueta and Rafael Radi},
  journal={ACS chemical biology},
  volume={4 3},
Peroxynitrite is formed by the very fast reaction of nitric oxide and superoxide radicals, a reaction that kinetically competes with other routes that chemically consume or physically sequester the reagents. It can behave either as an endogenous cytotoxin toward host tissues or a cytotoxic effector molecule against invading pathogens, depending on the cellular source and pathophysiological setting. Peroxynitrite is in itself very reactive against a few specific targets that range from efficient… CONTINUE READING
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