Chemical biology of lipidated proteins.

Abstract

Many signaling proteins such as the members of the Ras superfamily of GTPases are posttranslationally modified by covalent attachment of lipid groups, which is crucial for the correct localization and function of these proteins. Numerous lipidated proteins are oncogens often found mutated in several human cancers. Therefore, several therapeutic strategies… (More)
DOI: 10.1021/cb200460u

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Cite this paper

@article{Triola2012ChemicalBO, title={Chemical biology of lipidated proteins.}, author={Gemma Triola and Herbert Waldmann and Christian Hedberg}, journal={ACS chemical biology}, year={2012}, volume={7 1}, pages={87-99} }