Chemical biology of homocysteine thiolactone and related metabolites.

  title={Chemical biology of homocysteine thiolactone and related metabolites.},
  author={Hieronim Jakubowski and Rafał Głowacki},
  journal={Advances in clinical chemistry},
Protein-related homocysteine (Hcy) metabolism produces Hcy-thiolactone, N-Hcy-protein, and N epsilon-homocysteinyl-lysine (N epsilon-Hcy-Lys). Hcy-thiolactone is generated in an error-editing reaction in protein biosynthesis when Hcy is erroneously selected in place of methionine by methionyl-tRNA synthetase. Hcy-thiolactone, an intramolecular thioester, is chemically reactive and forms isopeptide bonds with protein lysine residues in a process called N-homocysteinylation, which impairs or… CONTINUE READING


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