Chemical basis of inflammation-induced carcinogenesis.

@article{Ohshima2003ChemicalBO,
  title={Chemical basis of inflammation-induced carcinogenesis.},
  author={Hiroshi Ayabe Ohshima and Masayuki Tatemichi and Tomohiro Sawa},
  journal={Archives of biochemistry and biophysics},
  year={2003},
  volume={417 1},
  pages={
          3-11
        }
}
Chronic inflammation induced by biological, chemical, and physical factors has been associated with increased risk of human cancer at various sites. Inflammation activates a variety of inflammatory cells, which induce and activate several oxidant-generating enzymes such as NADPH oxidase, inducible nitric oxide synthase, myeloperoxidase, and eosinophil peroxidase. These enzymes produce high concentrations of diverse free radicals and oxidants including superoxide anion, nitric oxide, nitroxyl… CONTINUE READING
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