Chemical aspects of siderophore mediated iron transport

@article{Boukhalfa2004ChemicalAO,
  title={Chemical aspects of siderophore mediated iron transport},
  author={Hakim Boukhalfa and Alvin L. Crumbliss},
  journal={Biometals},
  year={2004},
  volume={15},
  pages={325-339}
}
In this mini-review we describe selected aspects of the coordination chemistry relevant to siderophore mediated iron transport and bioavailability. Specific emphasis is placed on a discussion of in vitro kinetic and thermodynamic data that are relevant to elucidating possible in vivo mechanisms for environmental iron acquisition by microbial cells. 
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References

SHOWING 1-10 OF 77 REFERENCES
Transition Metals in Microbial Metabolism
Iron chelation and siderophores biosynthetic and regulatory aspects of fungal siderphores receptor-mediated bacterial iron transport structure and biochemistry of methane monooxygenase enzyme systems…
Pumping Iron Through Cell Membranes
Despite their importance in various cellular functions, the three-dimensional structure at atomic resolution has been determined for only a few membrane proteins. In his Perspective, Braun discusses…
Coordination chemistry of microbial iron transport compounds. 34. The pH-dependent reduction of ferric enterobactin probed by electrochemical methods and its implications for microbial iron transport
La chimie de coordination de l'enterobactine ferrique est prouvee par voltammetrie cyclique, polarographie normale et a impulsion differentielle ainsi que par electrolyse a potentiel controle. Effet…
Siderophore-Mediated Iron Transport in Microbes
Iron is an essential element for all living things (with the exception perhaps of a few bacteria in specialized environments). Incorporation of iron into biochemistry certainly occurred in the very…
Microbial iron transport via a siderophore shuttle: a membrane ion transport paradigm.
TLDR
It is shown that the siderophore and Fe(3+) enter the bacterium together, a ligand exchange step occurs in the course of the transport, and a redox process is not involved in iron exchange.
Solution equilibria of enterobactin and metal-enterobactin complexes
The solution thermodynamics of the siderophore enterobactin, a powerful iron chelator, and of the synthetic analogue MECAM (N,N',N″-tris(2,3-dihydroxybenzoyl)-1,3,5-tris(aminomethyl)benzene) have…
pH Induced Active (“Uphill”) Liquid Membrane Transport of Ferrioxamine B by the Ionizable Ionophore Lasalocid
Active transport of the siderophore ferrioxamine B by the ionizable ionophore lasalocid, driven by the pH difference in two aqueous phases separated by an artificial membrane, was observed with an…
CRC handbook of microbial iron chelates
TLDR
Chemists, biologists, biochemists, pharmacologists, and medical doctors interested in the general aspects of iron metabolism, siderophores, receptors, and iron complex formation should consider this book a rich information source.
Vitamin B12 transport in Escherichia coli: energy coupling between membranes
TLDR
The ability of extragenic suppressor mutations in tonB to correct the transport defect indicates that TonB couples the proton‐motive force to the outer‐membrane proteins by direct contact.
The structure of the ferric siderophore binding protein FhuD complexed with gallichrome
TLDR
The crystal structure of FhuD from Escherichia coli in complex with the ferrichrome homolog gallichrome has been determined at 1.9 Å resolution, the first structure of a periplasmic binding protein involved in the uptake of siderophores.
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