Chemical approach for specific enrichment and mass analysis of nitrated peptides.

@article{Lee2009ChemicalAF,
  title={Chemical approach for specific enrichment and mass analysis of nitrated peptides.},
  author={Jung Rok Lee and Seung Jae Lee and Tae Woo Kim and Jae Kyung Kim and Hyung Soon Park and Dong-Min Kim and Kwang Pyo Kim and Woon-Seok Yeo},
  journal={Analytical chemistry},
  year={2009},
  volume={81 16},
  pages={
          6620-6
        }
}
The analysis and detection of 3-nitrotyrosine are biologically and clinically important because protein tyrosine nitration is known to be involved in a number of biological phenomena such as cellular signal transduction, pathogenesis of inflammatory responses, and age-related disorders. However, the main obstacles in the study are low abundance of nitrated species and lack of efficient enrichment methods. Here in, we suggest a new chemical approach to analyze nitrated peptides using mass… CONTINUE READING
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