Chemical and radiochemical considerations in radiolabeling with α-emitting radionuclides.

@article{Wilbur2011ChemicalAR,
  title={Chemical and radiochemical considerations in radiolabeling with α-emitting radionuclides.},
  author={Daniel S Wilbur},
  journal={Current radiopharmaceuticals},
  year={2011},
  volume={4 3},
  pages={214-47}
}
A review of chemical and radiochemical factors that must be considered when radiolabeling targeting agents with radionuclides is presented. The review discusses factors that are important in choice of radionuclide and choice of chelation or bonding reagents to use in the development of an α-emitting radiopharmaceutical. Chemical parameters, such as physical properties and pendant groups for radiolabeling, are reviewed. A major portion of the review outlines the development of chelates and… CONTINUE READING