Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.

@article{Manchester2002ChemicalAP,
  title={Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.},
  author={Lucien C. Manchester and Russel J. Reiter and Mei-ting Yan and Mamdouh R El-Sawi and Rosa M S{\'a}inz and Juan C Mayo and Ron Kohen and Mario Allegra and Rudiger Hardeland},
  journal={Current topics in medicinal chemistry},
  year={2002},
  volume={2 2},
  pages={
          181-97
        }
}
Melatonin was found to be a potent free radical scavenger in 1993. Since then over 800 publications have directly or indirectly confirmed this observation. Melatonin scavenges a variety of reactive oxygen and nitrogen species including hydroxyl radical, hydrogen peroxide, singlet oxygen, nitric oxide and peroxynitrite anion. Based on the analyses of structure-activity relationships, the indole moiety of the melatonin molecule is the reactive center of interaction with oxidants due to its high… CONTINUE READING

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