Chemical and physical carcinogenesis: advances and perspectives for the 1990s.

  title={Chemical and physical carcinogenesis: advances and perspectives for the 1990s.},
  author={C. C. Harris},
  journal={Cancer research},
  volume={51 18 Suppl},
Carcinogenesis is a multistage process driven by carcinogen-induced genetic and epigenetic damage in susceptible cells that gain a selective growth advantage and undergo clonal expansion as the result of activation of protooncogenes and/or inactivation of tumor suppressor genes. Therefore, the mutational spectra of chemical and physical carcinogens in these critical genes are of interest to define endogenous and exogenous mutational mechanisms. The p53 tumor suppressor gene is ideally suited… CONTINUE READING


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